237 results
The primary objective of the proposed study is to investigate whether bumetanide therapy indeed reduces autistic symptomatology. Important secondary goals of this project are to determine whether bumetanide will improve specific behavioral,…
The purpose of the study is to investigate wether long-term resveratrol supplementation (6 months) leads to improved insulin sensitivity (estimated by Matsuda Index) in people with overweight/obesity. In addition we will investigate effects of…
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
What is the prevalence of gastro-intestinal disorders and which are the determinants?
Is to identify the incidence and prevalende of PH in premature born infants. In addition we will identify possible risk factors for the development of PH and we want to determine the prognosis and survival of these patients. PrimaryTo determine the…
Allogeneic hematopoietic stem cell transplantation is often complicated by graft versus host disease (GvHD) causing high morbidity and mortality. Loss of gutmicrobial diversity is a risk factor to develop GvHD. We will test the hypothesis that…
To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.
To assess in paediatric patients with ASD with and without (first-time) antipsychotic medication• the prevalence and incidence of insulin resistance and other metabolic abnormalities• the risk factors for insulin resistance and other metabolic…
This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…
We hypothesize that functional brain network measures may serve as a marker for (disrupted) neurodevelopment in very preterm born infants. Objective: we propose to perform two studies aiming to answer the following questions.Phase 1: Retrospective…
1. To get new insights in the pathophysiology of PPS by comparing tissue characteristics (histology) of the pericardium in patients with and without PPS. 2. To identify biomarkers that are associated with PPS by collecting 4 blood- and 1 pericardial…
We will investigate the effect of the combination of moderate physical activity and a standard meal on the onset of low grade intestinal ischemia. Will will use the serological biomarker I-FABP to determine the occurrence of low grade intestinal…
In this trial we now aim to investigate comprehensively the effect of riboflavin supplementation on the abundance of F. prausnitzii and on other members of the gut microbiota in faeces of healthy volunteers. Additionally we will assess whether…
The main objective of this study is to analyse the effect of preeclampsia on levels of memory T cell subsets in peripheral blood.
The projects is divided in 3 aims: 1) To evaluate the regenerative capacity of lung-derived MSCs (LMSCs) from normal and emphysematous lung tissue and compare LMCSs to MSCs derived from other tissues2) To investigate the interaction of MSCs with the…
The current research is set to provide insight into the phenotypic characteristics of DSPD patients in terms of psychological characteristics, occurrence of co-morbidities, and behavioural characteristics such as bedtime routines and lifestyle, and…
Primary Objective: To measure cortical spreading depression with full-band EEG during the migraine attack at patients aged 4 years or older. Secondary Objective(s): -To explore (additional) signal analysis techniques for detecting CSDs or infra slow…
1. To study the mechanisms that control endothelial and platelet secretion using blood outgrowth endothelial cells (BOECs) as an ex vivo model of endothelial and platelet secretion, in order to identify new regulators of and further unravel their…
The primary study objectives are: (1) to determine the impact of glioma and its treatment on the neurocognitive functioning, health-related quality of life, and mental functioning of LGG patients; and (2) to determine the impact of the disease and…
Primary objective: To investigate the effect of supplementation of a single intramuscular dose of 80 mg triamcinolone on the level of MPT-induced dynamic hyperinflation, in adult asthma patients with demonstrated dynamic hyperinflation. (Part 1)…