252 results
The aim of this study is to investigate the differences in organ-specific protein turnover rates by means of stable isotope labelled amino acid infusion in patients undergoing surgery. Primary objective:To compare protein synthesis rates, expressed…
* To estimate the prevalence of hyposalivation and xerostomia in pediatric cancer survivors treated with different cancer regimens (e.g., H&N RT, TBI, CT, or those who developed cGVHD following allogeneic stem cell transplantation).* To…
to assess the pulmonary toxicity in patients treated with cyclophosphamide compared to a control group
To study cognitive and behavioral outcome and resting-state dynamics in children with a history of perinatal asphyxia before and after the introduction of hyothermia and to compare these data with a group of controls.
The primary objectives of this study are: 1. To examine the effect of cold acclimation on cardiovascular risk parameters in type 2 diabetic patients. 2. To study if the previously observed effect of cold acclimation on insulin sensitivity in type 2…
The aim of this study is to compare glomerular filtration rate (GFR) in very long-term TC-survivors treated with chemotherapy, radiotherapy or surgery only and non-cancer treated healthy controls. Furthermore, a secondary aim is to assess prevalence…
Primary Objective: Identification of patient characteristics, echocardiographic measurements and biomarkers that can contribute to a better selection of patients that benefit from percutaneous ASD closure at adult age. Secondary Objectives:-…
Objective: The objective of the prospective NAFLD cohort study with biobank is: 1. In a cross-sectional design (a) to determine which factors are associated with the presence of NASH in a population of NAFLD patients and (b) to identify and validate…
1. Investigate health care consumption of patients with bilateral vestibulopathy2. Investigate patient expectations of the vestibular implant3. Define inclusion criteria for vestibular implantation4. Define diagnostic approach for patients with…
1. To investigate the size of the HCHWA-D population by identifying all (possible) mutation carriers and their relatives. 2. Study the genealogy and natural disease history of these carriers.3. Get insight in possible genetic, environmental and…
Primary Objective: Identification of genetic variants causative of CHD. Expression of candidate genes in a zebrafish model. Overall goal is to gain insight in cardiac development by expanding our knowledge of genetic components in de novo and…
The iBerry Study, phase 2, has two related main study objectives:1) Describing the long-term prognosis of sub-threshold symptoms in terms of course (transition to several full-blown psychiatric disorders, chronicity, recurrence, comorbidity) and…
The objective of the study is to investigate if predictors of cardiac responsiveness are able to predict a renal response to fluid administration in oliguria.
The primary objective is to test the hypothesis that endometrial scratching in the cycle preceding controlled ovarian stimulation in women with implantation failure (defined as failure to achieve an ongoing implantation after having completed a full…
Primary Objective: To assess the difference in prevalence of pituitary dysfunction between patients with and patients without fatigue after ischemic stroke. Secondary Objectives: 1. To assess the time course of pituitary dysfunction after ischemic…
• To evaluate the proportion of childhood cancer survivors that reach peak bone mass• To evaluate the incidence rate of fractures of CCS as compared to normal controls• To investigate patients at (treatment or diagnosis related) risk for decline of…
This DCOG-LATER project proposal aims to characterize the overall, disease and treatment-related risks of sexual dysfunction and delays in psychosexual development in a Dutch cohort of 5-year CCS treated in the period 1960-2001 and to evaluate the…
The main objective of this study is to investigate whether rTMS add-on treatment will improve clinical outcomes in alcohol dependence. The secondary objective will be to answer the question through which mechanism rTMS will improve treatment…
The primary objectives are to determine the inhibitory effect of intravenously administered C1-inhibitor as well as the influence of depletion of the human microbiota on allergic lung inflammation induced by house dust mite (HDM) plus…
1. To establish optimized approaches for the isolation and characterization of BOECs and iPSC-ECs2. To further explore the biology of VWF, the pathophysiology of different subtypes of VWD and the role of VWF as a signalling protein in for example…