256 results
Can mitochondrial dysfunction (especially reduced complex I activity) be observed in skeletal muscle samples from patients with autosomal recessive PD (in this pilot study, parkin parkinsonism)?The project is expected to (a) clarify the possible…
The objective of the study is to assess whether in young patients with arteriopathic stroke perfusion abnormalities in non-infarcted brain are associated with the type and course of arteriopathy and stroke outcome in terms of functional recovery and…
To study whether higher estradiol levels in obese men are responisble for the lower testosterone levels also found in these men
1. How is the development of cognition over the time period of one year, assessed by the MATRICS cognitive test battery, in a study population of First Episode Schizophrenia patients and Ultra High Risk subjects?2. What is the potential predictive…
The first aim in the proposed project is to directly test the alleged role of working memory on (explicit) motor skill learning in preterm children. Our second aim is to examine the relation between implicit and explicit learning in preterms. This…
1.To describe whether vascular lesions are more frequent in elderly heart failure patients compared to elderly patients with cardiovascular disease but no heart failure.2.To describe the association between these vascular lesions and executive…
-
Our research proposal has several aims: 1) We propose to use large-scale genetic studies to identify allelic variants that influence the development of AMD, which will enable the development of diagnostic and prognostic tools in the near future. 2)…
zie samenvatting
The goal of the study is to gain insight in the changes in motor control programming after injury to the ACL and subsequent reconstruction of the ACL. The following hypotheses: will be tested:1. Reflex latencies on the involved side are increased…
To identify (low-grade) inflammatory signs in patients with symptomatic hand OA using ultrasound. Secundary to investigate whether clinical symptoms such as pain and disability, and radiological status correlate with (low0grade) inflammation and…
- To determine physical fitness in children with a congenital heart disease (ventricular septum defect, atrium septum defect, tetralogy of Fallot, transposition of large arteries and patients after a (modified) Fontan-operation) and to compare…
The project is focused on induction of immune tolerance in allergy by prebiotics. The pathophysiology of immune modulation will be investigated and searched for potential biomarkers for immune modulation.
Objective: to provide an answer to the following question: in patients with AD, does treatment with a ChEI improve cerebral autoregulation?
Primary Objective: What is the frequency of positive patch test reactions to the 26 declarable fragrance allergens in fragrance mix I and/or II positive participants?Secondary Objectives: Do Weleda cosmetic products containing essential oils,…
Objectives1. Achieve a complete ascertainment of incident CIAP patients in the middle of the Netherlands during a three-year period and determine the frequency of CIAP.2. Establish whether CIAP is associated with the metabolic syndrome, and if so,…
Objective of this study is to investigate cytokine production and expression of toll-like receptors on monocytes in blood samples from pregnant and non-pregnant women using sonicates from different types of oral pathogenic micro-organisms and…
1. Is EC dysfunction, measured by PWA, present RA patients?2. Is EC dysfunction in RA related to EC activation markers (CRP, thrombomodulin, sVCAM, vWF), AGEs, and the presence of atherosclerosis?3. Is EC dysfunction related to traditional…
Primary objective is to show the presence of endogenous ligands of TLR4 in the lung of patients being mechanically ventilated in a standardised way with clinical parameters. Secondary objective is to investigate the amount of endogenous ligands of…
Studie A:1. To study the psychometric properties of the Dutch version of the PIQ in a non-clinical and clinical sample.2. to study the relationship of persecutory delusions and aggression in a non-clinical and clinical sample.Studie B:3. To test the…