125 results
We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
Primary Objective: To determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxisSecondary Objectives:• To determine the dose-dependent protective efficacy of NF135.C10 CPS-immunization against homologous…
By providing patients reliable information and daily checklists via an app, we aim to give the patient a tool to be involved in the management of the catheter use. In this way, inappropriate use should be better signaled and discouraged, and the…
Primary Objective: To compare the composition and functionality of neonatal microbiome arising from mothers receiving antibiotic prophylaxis before skin incision with the microbiome of neonates born when antibiotics are given after umbilical cord…
Is additional protein delivery directly after mobilization effective in delaying muscle atrophy (measured by muscle thickness determined with ultrasonography) in subjects with critical illness compared to early mobilization and continuous protein…
The primary objective is to evaluate the efficacy of the serious game *Toap Run* on gait and balance outcomes in patients with PD. Secondary objectives include assessing the effects of the game on disease symptoms, spatiotemporal gait parameter and…
- The main objective of this study is to develop a predictive model that can estimate the rest energy expenditure in indviduals with SCI or LLA.- To develop a model based on raw accelerometry data that can estimate the energy expenditure during ADL…
To determine the prevalence of BPPV in the elderly patients with an increased risk of fallsSecondary ObjectivesTo compare the outcomes within BPPV patients before and after successful treatment with a canalith repositioning manoeuvre (CRM):* The…
The primary objective is to evaluate in the two targeted populations (i.e. CD and self-reported NCGS subjects):1) the safety profile of BL NCC 2705 2) the gastro-intestinal (GI) tolerability of BL NCC 2705
The primary objective is to test the hypothesis that galcanezumab is superior to placebo in the prevention of migraine in patients with treatment-resistant migraine.The key secondary objective are:- To compare galcanezumab with placebo with respect…
Aim of the MIRRE pilot study is to determine how much the primary inoculation dose of diarrheagenic E. coli should be lowered in order to result in a reduced protective response upon a secondary infection.
1.3. Study Design Rationale The ATLAS-PPX trial (ALN-AT3SC-009) is a multicenter, multinational, open-label Phase 3 switching study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B, with inhibitory…
This is the first study to create and investigate the effectiveness of a multi-component intervention protocol in students with sleep problems. The aim is that such an intervention, combining cognitive-behavioural therapy for insomnia, mindfulness,…
To develop a prediction equation to validly estimate the body composition of people with a SCI using bioelectrical impedance analysis (BIA)To develop a prediction equation to validly estimate the resting energy expenditure of people with a SCI from…
The primary objective is to test the feasibility (Study 1) and the effectiveness (Study 2) of using self-tracking device and web-based coaching platform to increase PA levels among patients in the early CR process. Effectiveness of the new approach…
To examine the effect of a physical activity intervention on executive functioning, mental health and academic achievement in healthy adolescents. The secundaire objective is to examine the effect of a physical activity intervention on physical…
To increase our knowledge about bats as a potential source of zoonotic viruses in the Netherlands, and to support evidence-based development and evaluation of prevention and management tools against (in)direct virus transmission from bats to humans…
The primary objective of this study is to explore characteristics (nutritional status, body composition, and presence of comorbidities) of HD patients related to successful individual application of bio-electrical impedance to determine the endpoint…