9 results
Primary ObjectiveThe primary objective of this study is to assess whether the antidepressant response to IV ketamine can be maintained by minocycline compared to placebo.Secondary ObjectivesThe secondary objectives of this study are:* To investigate…
The objectives are to assess the pharmacokinetic and pharmacodynamic effects of sub-anesthetic ketamine administration, to assess the optimal dose of ketamine and gender differences, to compare different oucome measures for psychomimetic symptoms…
The aim of this study is to find a directly applicable intervention for acutely suicidal patients, so that the risk of these patients committing suicide is substantially lowered, leading to fewer actual suicides. To this end we propose a randomized…
1. Define risk profiles based on retrospective data in a cohort of bipolar patients. These profiles will be based on the effects of various combinations of MR and GR genotypes involved in stress regulation on symptoms, course of the illness and…
Primary objectiveTo evaluate the CNS effects of a single intravenous dose of ketamine on functional brain networks by performing resting state functional magnetic resonance imaging (fMRI) in major depressive disorder (MDD) patients who fail to…
The purpose of this study is to investigate the effect size in order to perform a power calculation for calculating a sample size for a powered RCT
The primary objective of the study is to determine whether TAK-653, in comparison to placebo, increases CNS excitability, assessed with TMS-evoked MEP in healthy subjects.Next to that, the study has the following goals: - To determine whether TAK-…
The primary objective to demonstrate that in CNOpatients with pain 3-monthly treatment with pamidronate will result in significant decrease in maximum pain score (as measured with BPI) as compared to placebo.Secondary objectives:•…
The aim of this study is to find a directly applicable intervention for acutely suicidal patients, so that the risk of these patients committing suicide is substantially lowered, leading to fewer actual suicides. To this end we propose a randomized…