8 results
Primary objectives: 1) Phase Ib: To estimate the MTD or RP2D of INC280 in combination with gefitinib in NSCLC patients who have c-MET dysregulation. 2) Phase II: To estimate overall clinical activity of INC280 in combination with gefitinib in NSCLC…
To study the effect of intensive blood glucose control intraoperatively and 24 hours postoperatively on the occurrence of cardiovascular complications and death from all causes at 30 days and at 1 year after non-cardiac surgery in diabetics.
To determine whether glucose, lipid and protein metabolism can be accurately measured using stable isotopes in the same patient on two occasions in a 48 hour interval.
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…
Evaluate the outcomes of a relatively brief but intensive IV insulin therapy compared to conventional therapy in patients admitted for ACS and observe different biomarker washout patterns these treatment groups.Furthermore we wish to determine…
To study the role of central insulin on glucose metabolism.
To assess the anti-tumor activity of LGX818/MEK162 in combination with third targeted agents after progression on LGX818/MEK162 combination therapy.
Primary objective: To evaluate the effect of treatment with oral hypoglycemic agents (OHA) on the incidence of large-for-gestational-age (LGA) infants in women with GDM requiring medication, compared to insulin (INS) treatment.Secondary objectives:…