4 results
Primary:To determine the safety, tolerability, and pharmacokinetic (PK) profile of single ascending intravenous (iv) doses and of multiple ascending iv doses of FMX-8 in healthy subjectsSecondary:To evaluate the pharmacodynamics (PD) of FMX-8 in…
To characterise and compare neurobiological mechanisms underlying behavioural effects of three different rTMS treatment protocols in OCD using multimodal neuroimaging, with a focus on neuroplasticity.
Primary objectives (Dose-escalation Phase):• To evaluate the safety and tolerability, describe the dose-limiting toxicities (DLTs), to determine the maximum tolerated dose (MTD), optimal biological dose (OBD), or highest protocol-defined dose (HPDD…
Hypothesis: 5 day multi daily neuronavigated Theta burst sessions (developed by Stanford University and coined, SNT, i.e. Stanford NeuromdulaTion protocol) are more (cost-) effective than standard 10 Hz rTMS in patients with treatment resistant…