17 results
The aim of the study is to compare magnesiumhydroxide and polyethylene glycol/electrolytes with regard to the prevention of constipation and side-effects in palliative care cancer patients starting with opioids.
The primary objective is to investigate the influence of vigilance state on MEP amplitude in healthy adults. Secondary objectives are to develop a paradigm to stabilize vigilance state resulting in lower MEP amplitude variability in healthy adults…
The goal of the current study is to investigate the functional relevance of higher order cortical areas for cognitive task execution involving inhibitory and emotional processes by means of TMS.
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
We plan to (1) prove that microTMS can influence brain connectivity in healthy volunteers, and (2) optimize the stimulation parameters. As soon as a considerable effect is obtained, the new project will follow up for patients.
Primary Objective:In this pilot study, the authors aim is to investigate whether esketamine reduces the incidence of POD in elderly patientspresenting for noncardiac surgery.Secondary Objective(s):To examine whether esketamine has an effect on the…
Aims of the Study: Our main aim is to characterize cortical brain plasticity in individuals with impaired fasting glucose (IFG) and patients with type II diabetes mellitus (DM2) as compared with age-, gender-, and IQ-matched healthy controls(HC).•…
Primary ObjectiveTo evaluate the effect of a single 84-mg dose of intranasal esketamine compared to placebo, on next day driving performance and repeated administration of 84 mg intranasal esketamine on same-day driving performance as assessed by…
The aim of this study is to demonstrate that procedural sedation with propofol and esketamine is more effective and will result in less cardiopulmonary depression than sedation with propofol and the opioid alfentanil. Less side effects should also…
The main objective of this study is to investigate whether rTMS add-on treatment will improve clinical outcomes in alcohol dependence. The secondary objective will be to answer the question through which mechanism rTMS will improve treatment…
To explore whether influence on parasympathetic activity can be used as a functional outcome measure reflecting adequate targeting of the DLPFC-sgACC network and, secondary: 1) to explore the dose-response to the intensity of the TMS output and 2)…
Can this effect be utilised clinically, especially in patients with major depressive disorder?
To evaluate the effect of intranasal esketamine 84 mg on cognition, and duration of cognitive effects (if present), as assessed using a computerized test battery (Cogstate®).
Objective 1: To determine the effects of S-ketamine on brain activation in healthy women, healthy women prone to depression and fibromyalgia patients.Objective 2: To determine the effects of S-ketamine on mood and other depression-related behavioral…
Primary objective:The primary objective of this study is to evaluate the efficacy of flexibly dosed esketamine nasal spray compared with quetiapine extended-release(XR), both in combination with a continuing selective serotonin reuptake inhibitor (…
Primary Objectives* To investigate the effects of PO and IV S-ketamine and its metabolite S-norketamine on functional CNS tests up to 6h (acute effects) and 24h (delayed effects) after administration using NeuroCart test battery in healthy subjects…