4 results
Aim of this study is to investigate the effects of oral administration of GTS-21 in healthy volunteers on cytokine release in ex-vivo TLR agonists stimulated whole blood . Pharmacokinetic and pharmacodynamic data will be collected with respect to…
to study the effect of pre-treatment with the specific a7nAChR agonist GTS-21 on cytokine production and the effects on the subsequent subclinical organ dysfunction in the human endotoxemia model. to measure the effect of LPS administration in the…
To study the safety and efficacy of mitapivat in the treatment of adult subjects with sickle cell disease.
To address whether the individualized fludarabine conditioning reduces the incidence of severe viral infections at day 100 within the context of an αβTCR / CD19 depleted transplantation regimen.