10 results
In this study we attempt to determine if there is any difference between cannulation of the RIJV using the blind landmark technique or the ultrasound technique performed by a trainee in anesthesia (in his/her second year of education) with…
Primary objective: To validate mpUS as imaging modality for detection and localization of prostate cancer by direct correlation of mpUS imaging and its parameters with histopathology of the resected prostate.Secondary objective: see Protocol paper,…
Primary (PART 1A ONLY):Dose escalation: To determine the safety, tolerability, and the recommended phase 2 dose (RP2D) of GSK3745417 alone administered intravenously to participants with selected advanced/recurrent solid tumors.Secondary: (PART 1A…
In last decades, ultrasound probes have become smaller, which made adequate intraoral ultrasound of oral tumors possible. Therefore, invasion depth is now determined pre-operatively by intraoral ultrasound for staging of oral cancer. Our feasibility…
Primary objective:To estimate the efficacy of dostarlimab in participants with Stage II/III (locally advanced) dMMR/MSI-H rectal cancer that has not been previously treatedSecondary Objectives:- To further estimate the efficacy of dostarlimab in…
Primary objective: To assess the validity of US to measure lean mass after weight loss in a population of bariatric surgery patients.Secondary Objectives: • To assess de differences in lean mass between DXA and US in this study compared to the…
The aim of this research is to decrease the number of involved margins, resulting in less adjuvant therapy and less local recurrences.
This study is looking at how safe the combination of the experimental drugs dostarlimab, belrestotug and GSK6097608 is in patients with previously untreated, advanced or metastatic non-small cell lung cancer. And how well the combination works. We…
A relatively new method to determine margin distance is intraoral resection with a small Ultrasound (US)-probe. US is already used to determine tumor-thickness in tongue cancer preoperatively, because of its high predictive value. Four previous…
DOSE EXPLORATION:Primary:To determine the safety and tolerability of GSK2857916 in combination with other anti-cancer treatments (in each sub-study), and to establish the recommended Phase 2 dose for each sub-study combination treatment.Secondary:…