4 results
Primary objective:Does perioperative maintenance of cardiac output and pulse pressure variation result in an overall reduction in postoperative complications when compared to arterial blood pressure-guided perioperative hemodynamics in patients…
* To evaluate the safety and tolerability of adding multiple oral doses of HTL0018318 in elderly volunteers taking donepezil at steady state.* To compare the pharmacokinetic profiles of HTL0018318 and donepezil when given alone and in combination at…
Primary objectivesPart 1To evaluate the single dose safety and tolerability of donepezil 10 mg when administered with placebo, glycopyrrolate or trospiumPart 2To evaluate the safety and tolerability of donepezil when given with concomitant placebo,…
The aim of this research is twofold:1) Determining the functionality of the oxygen sensor in the neck (the glomus body or *carotid body* during the administration of glucose and insulin, a so-called euglycemic hyperinsular clamp.2) Validating a new…