4 results
Primary:to investigate the effects on heart rate (HR) and rhythm of concomitant administration of the study drug with a calcium-channel blocker (CCB) or a beta-blocker (BB)Secondary:- to investigate the effects on blood pressure (BP) of concomitant…
Primary:to evaluate the effects of a moderate CYP3A4/5 inhibitor, diltiazem on the pharmacokinetics and pharmacodynamics (Thrombin and TRAP-induced platelet aggregation) of the study drug and its known metabolitessecundary:to evaluate the effects of…
Reducing postoperative pain and nausea improves patient satisfaction.
To assess whether patients receiving simple hallux valgus surgery ambulate independently earlier after spinal anesthesia combined with LIA, compared to popliteal blocks. We hypothesize that both groups will demonstrate sufficient pain relief.