8 results
To assess whether treatment with DBS can reduce or resolve TDD and if DBS can induce beneficial or side effects in particular psychiatric and or cognitive symptoms.
The goal is to assess the effect of MGB-DBS on tinnitus severity. Secondary objectives are:- To assess side effects of MGB-DBS on hearing and neuropsychological functioning.- To explore neurophysiological hallmarks.
The primary objective is to investigate the cognitive effect of low-frequency stimulation of the nucleus basalis of Meynert (NBM) in advanced Parkinson*s disease (PD) patients, who were previously treated with deep brain stimulation (DBS) of the…
This study will provide an estimate of basic PK parameters for guadecitabine, an assessment of the routes and rates of elimination of radioactivity, and identification of metabolites and metabolic pathways.
Establishing efficacy and safety of the electrodes and implantable pulse generators (IPGs), which are used for deep brain stimulation (DBS) in patients with obsessive-compulsive disorder (OCD).
In this study, we will test whether STN-DBS related apathy can be reversed by switching stimulation to a more dorsal contact on the electrode.
Main Phase:To demonstrate the superiority of medium-dose BDP/FF/GB pMDI compared to high-dose BDP/FF pMDI in terms of the proportion of subjects exhibiting on average NPAL over 26 weeks of treatment in the study sub-population with PAL at screening…
Establishing efficacy of MFB DBS for TRD by comparing active DBS with sham DBS. Secondary aims are establishing an adverse events profile, establishing effects on quality of life, cost-effectiveness, (neuro)psychological and neuroimaging measures.