10 results
Primary aim:The primary aim of this study is to evaluate the effect of two consecutive infusions of S(+)-ketamine in patients with CRPS-I on pain relief. The design of the study is prospective, randomised, double-blind and placebo-controlled.…
To test the hypothesis that ketamine has a modulatory effect on fibromyalgia
1. Measure DNIC and offset analgesia in CRPS-1 patients, fibromyalgia patients and neuropathic pain patients;2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers;3. Assess the effect of…
This study is therefore aimed at quantifying the relative contribution of the two major receptor systems involved in S(+)-ketamine and methadone induced analgesia and side effects (respiratory depression, sedation, miosis).
By means of resting state network measurments using fMRI we hope to gain more knowlegde about the actions (for example as an analgesic) an side effects of S(+)-ketamine on the central nervous system at different doses. Also blood samples will be…
Aims of the study:1) To obtain pharmacokinetic parameters of S(+)-ketamine;2) To study the pharmacodynamic effects of intravenous S(+)-ketamine on experimental pain;
The objectives of the study are to assess whether:(1) SNP will reduce the occurrence of psychomimetic side effects during exposure to low-dose ketamine;(2) SNP will reduce the ketamine-induced increase in blood pressure and cardiac output;(3) SNP is…
We hypothesize that ketamine stimulates breathing and reverses opioid-induced respiratory depression. We will perform a placebo-controlled randomized and double blind study on the effect of increasing doses of S-ketamine on remifentanil-induced…
The primary objective of this study is to evaluate the feasibility of the Pentax CADe-system during colonoscopy procedures in terms of the polyp detection rate (PDR). We hypothesize that the use of the Pentax CADe-system is feasible and enables…
The primary objective of the study is to compare the ADR between PCSC and CC in patients referred for diagnostic, screening (non-iFOBT based) or surveillance colonoscopy.Secondary objectives are the following:- To compare the polyp detection rate (…