6 results
Primary objective * To determine the maximum tolerated dose and recommended dose of metformin plus chloroquine in patients with IDH1/2MT glioma, IHCC and CS Secondary objectives * To describe the toxic effects of metformin plus chloroquine in…
To determine the toxicity of adding chloroquine in escalating doses in patients with small cell lung cancer to standard therapy.
The aim of this study is to collect data in a structured way in order to explore the tolerability, safety and efficacy of paliperiode ER with treatment schedules which will be used in future clinical practice.
To determine the toxicity of adding chloroquine in escalating doses in patients with small cell lung cancer to standard therapy.
What is the prevalence of gastro-intestinal disorders and which are the determinants?
Primary objective• To determine the MTD/RPTD for CQ in combination with concurrent radiotherapy with daily TMZ in patients with a newly diagnosed GBM.Secondary objectives• To characterize the safety and tolerability of CQ in combination with…