4 results
To evaluate the safety, tolerability and pharmacokinetics of RO5428029 in healthy male subjects.
To identify the preferred method of bladder catheterisation in patients undergoing abdominal surgery (either vascular or gastro-intestinal surgery).
Primary: To estimate the antitumor activity (assessed as overall response rate) of PDR001 as a single agent in patients with non-functional neuro-endocrine tumors (NET).Secondary: To estimate efficacy (duration of response) of PDR001. Safety and…
* Safety Run inTo determine the recommended regimen of PDR001 in combination with dabrafenib and trametinib for the randomized part (part 3)* Biomarker cohortTo evaluate changes in the immune microenvironment and biomarker modulations upon treatment…