6 results
The objective of this study is to evaluate the efficacy of oral cabozantinib at adaily dose of 60 mg compared with 140 mg in subjects with progressive,metastatic MTC.
Primary Objectives: To describe the morphology of the carpal tunnel and median nerve 6 months after primary carpal tunnel release using ultrasonography and the electrophysiological properties of the median nerve as found by nerve conduction studies…
To demonstrate that a dose reduction of 20-33% of CYP3A4 metabolized tyrosine kinase inhibitors in patients expressing the CYP3A4*22 gene (rs35599367 C>T in intron 6) does not result in a lower exposure (Ctrough) than the wildtype group with…
To evaluate the 2.9 mm JuggerKnot Soft Anchor in arthroscopic rotator cuff repair regarding (1) orientation, dimensions and remodelling of the bone tunnel after anchor placement (e.g. cyst formation, osteolysis), (2) integrity of the rotator cuff…
To assess the objective response rate (ORR), progression free survival (PFS), overall survival (OS), duration of response (DoR), toxicity, and quality of life (QoL) of patients with advanced SGC treated with cabozantinib in 3 cohorts: salivary duct…
Dose-Escalation Stage (Combination Therapy Cohorts):The primary objective is as follows:• To determine the maximum tolerated dose (MTD) and/or recommended dose and schedule for the subsequent Expansion Stage of daily oral administration of…