5 results
Given the significant number of patients with OIPN and the possible prophylactic properties of venlafaxine, this study is designed. This study will consist of a randomised placebo-controlled clinical trial to study the prophylactic effect of…
Inhibition of CYP2D6 enzymes by SSRIs may lead to reduced endoxifen plasma concentrations and thereby possibly influence tamoxifen treatment outcome. Paroxetine is a potent CYP2D6 inhibitor and strongly reduces endoxifen plasma concentrations.…
Primary: To determine whether treatment with BKM120 plus fulvestrant prolongs PFS based on local investigator assessment compared to treatment with placebo plus fulvestrant for all patients regardless of PI3K pathway activation status (unkown status…
The main goal is to identify risk factors for radiation induced cognitive changes. Therefore, cerebral hemodynamic status of the patient, measured as cerebrovascular reactivity (CVR) with magnetic resonance imaging (MRI), at the start of radiation…
To determine safety and efficacy of low molecular weight dextran sulphate during islet transplantation