3 results
Primary study objectives:· To determine the safety [(adverse event profile, dose-limiting toxicity (DLT) and maximum tolerated dose (MTD)] of JNJ-26483327in male and female subjects with cancer.· To determine the pharmacokinetics (PK) of JNJ-…
Phase Ia: (dose escalation):- To determine the maximum tolerated dose (MTD) and a recommended Phase II dose (RP2D) for M3814 (also referred to as MSC2490484A) in combination with fractionated palliative radiotherapy (RT) for tumors or metastases…
To gain insight into the full spectrum of temperature-induced changes in glucose homeostasis, the present study will be aimed at assessing the effect of acute whole-body heat exposure on liver insulin sensitivity, substrate oxidation and plasma…