3 results
Primary Objective: Studying the phenomenon of tolerance by evaluating pharmacokinetic- and dynamic parameters, in patients receiving long-term ITB therapy.Secondary Objective(s): 1.To specify the intrathecal pharmacokinetics and -dynamics of…
The primary objective is to assess the relative bioavailability of TMC207 after single-dose administration of 100 mg of TMC207 as water dispersible tablets or granules using a 100-mg tablet formulation as the reference, with and without food.
Hypothesis #1 efficacyWe hypothesize that a quick onset and a good adjustability of analgesia can be achieved with inhaled ketamine.Hypothesis #2 safetyInhalation of nebulized ketamine might lead to a fast onset of analgesia, with limited adverse…