9 results
The primary objective of the study is to demonstrate the antitumor activity of LDK378.
Primary: To assess the steady-state PK of 450 mg or 600 mg ceritinib taken daily with a low-fat meal as compared with that of 750 mg ceritinib taken daily in the fasted state in patients with metastatic ALK-positive NSCLC.Secondary: Overall response…
The primary objective is to evaluate the antitumor activity of ceritinib in patients with ALK-positive NSCLC metastatic to the brain and/or toleptomeninges based on whole body overall response rate (ORR), defined as the proportion of patients with a…
Primary Objective: The aim of this study is to research the effect of a computerized cognitive rehabilitation program (RehaCom) in post COVID-19 patients with cognitive complaints on their sustained and divided attention and their working memory.…
Primary: 1. To determine the MTD and/or RDE of the combination ceritinib and nivolumab. 2. To assess the preliminary antitumor activity of the combination.Secondary: 1: To assess the safety profile of the ceritinib and nivolumab combination. 2: To…
To compare the effect of two automated oxygen controllers (Oxygenie and CLiO2) on time spent within oxygen target range in preterm infants.
The primary objective is to compare the antitumor activity of LDK378 versus reference chemotherapy.The key secondary objective is to compare Overall Survival (OS) in patients treated with LDK378 versus reference chemotherapy (pemetrexed or docetaxel…
The overall aim of the present study is to develop and test a cognitive rehabilitation intervention for OHCA patients with cognitive deficits. The intervention will be designed to improve cognitive functioning in the domains of attention, memory,…
The primary objective is to compare the antitumor activity of LDK378 versus reference chemotherapy