7 results
To determine the pharmacokinetics of two high dose regimens of intravenous vitamin C in critically ill patients, in particular the attained plasma concentration and the fraction retained in the body and excreted in urine.
PrimaryImproved woundhealing in 30 days in patients with an open revascularisation of the lower extremities after treatment with 4 dosages of 2 grams ascorbic acid on 4 consecutive days. (First dosage 1 hour preoperative)SecondaryWith preoperative…
The evaluate which treatment of mallet fingers is better, the conventional mallet therapy via the hospital or the personalized treatment with intensive follow up via the handencentrum. This will be investigated for mallet fingers caused by an…
To assess whether there is a difference in the outcome in treatment of acute mallet fingers (exist <2 weeks) compared to chronic mallet fingers (exist > 4 weeks), using the same protocol of intensive follow-up by the '…
Primary* To estimate the effect of NME combination therapies on inducing a functional cure over the control arm.Secondary * To characterize the efficacy profile of NME combination therapies.* To characterize the PD profile of NME combination…
The aim of this study is to examine the effect of vitamin C supplementation on immune recovery in patients with autologous stem cell transplantation. The aim of the run-in phase of the study is to examine the effect of intravenous vitamin C…
Objectives:- To determine whether an early high dose i.v. vitamin C can improve organ function, especially neurological outcome, in patients after cardiac arrest- To explore the optimal dosing regimen for high dose i.v. vitamin C- To investigate in…