9 results
To study the effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers 7 days post-administration.
This is an open label proof of principle study, in 14 patients. The objective of the study is to test the efficacy and safety of ARA 290 in patients with active rheumatoid arthritis. To assess the efficacy, disease activity is examined based on…
To determine the relative bioavailability of pramipexole 4.5 mg tablets vs. 4.5 mg Sifrol in healthy subjects after up-titration.
ARA290 is a new drug against neuropathic pain and was succesfully tested in previous studies on patients with neuropathic pain due to diabetes and sarcoidosis. The current study involves sarcoidosis patients with pain due to neuropathy. The purpose…
To measure the PK of ARA290 when given in de SQ form
To measure the plasma conc. of ARA 290 in healthy volunteers
In this study we will assess the effect of ARA290 on nerve damage by taking 4 skin bipsies during treatment.
To assess the analgesic effect of ARA290 in chronic pain patients
The main parameter of this study is the objective quantification of the biomechanical properties of skin and keloid/hypertrophic scars, as compared to the golden standard (Cutometer).The discriminating capacity will be tested by comparing healthy…