4 results
To compare the effect of amiloride on lithium-induced Nephrogenic Diabetes Insipidus with the effect of hydrochlorothiazide, measured as urine volume and maximal urine osmolality.
(1) to establish the effect of adding amiloride to lithium- treatment on the progression of renal insufficiency in patients with lithium- nephropathy (2) to answer the question whether adding amiloride to the use of lithium has the same effect as…
The purpose of the study is to investigate how quickly and to what extent radiprodil is absorbed and eliminated from the body (this is called pharmacokinetics). It will also be investigated to what extent radiprodil is tolerated. In addition, 2 new…
Primary objective: to investigate the effect of amiloride on urine volume and urinary concentrating ability in patients on chronic lithium therapy suffering from polyuria.We hypothesize that amiloride therapy will improve urinary concentating…