9 results
In the present proposal, we aim to answer whether antenatal allopurinol administration does reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia.
Primary objective: Investigating whether 50 mg allopurinol is non-inferior to 100 mg in combination with azathioprine or mercaptopurine by measuring and comparing thiopurine metabolites Secondary objectives:-Comparing patient tolerability in terms…
The primary study objective is to determine whether Febuxostat daily 80-120 mg is better than Allopurinol daily 100-600 mg in inducing positive changes in Pulse Wave Velocity (PWV) after 36 weeks of treatment.
To compare the efficacy and safety of lenalidomide versus placebo maintenance therapy (standard care).
To test whether the proportion of patients in remission during the last 6 months of follow up is higher for a T2T strategy compared to a T2S stop strategy.
Phase 2:Primary ObjectivesTo determine the recommended Phase3 dose of mitapivat by evaluating the effect of 2 dose levels of mitapivat versus placebo on:• Anemia in subjects with sickle cell disease (SCD)• SafetySecondary ObjectivesTo evaluate the…
Primary objectives pancreatic cancer:• In this clinical pilot study, we will assess the effect size to perform a power calculation for a subsequent clinical trial. Therefore we want to evaluate the ability of metabolic 7T MRI imaging to determine…
The GO TEST OVERTURE study aims to demonstrate the superiority of the Treat to Target management strategy over a Treat to Avoid Symptoms approach in terms of clinical remission of gout symptoms.
Primary objective: To assess feasability of DMI for intrahepatic tumor detection. Secondary objectives: - Head-to-head comparison between DMI and FDG-PET/CT for intrahepatic tumor detection.- Assessment of requirements for spatial resolution and…