13 results
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
In preparation for a large multi-center trial on the efficacy and safety of SENS for chronic intractable angina pectoris, we want to conduct a pilot, explorative trial to assess the feasibility, safety and efficacy of SENS implantation in this…
Primary: To characterize safety and tolerability of each treatment arm tested and identify recommended doses and regimens for future dosesSecondary:* To characterize the pharmacokinetic profile of each investigational drug within each treatment arm…
The objective of this study is to evaluate the efficacy and safety of upadacitinib versus dupilumab for the treatment of adult subjects with moderate to severe atopic dermatitis who are candidates for systemic therapy.
With this study we aim to improve the current ocular MRI protocols and assess its additional value in the diagnosis and therapy planning of UM.1. Extend the current 7T MRI protocols to provide information to differentiate tumour types.2. Translate…
Primary Objectives: - Assess the feasibility and clinical value of 7T MR to provide a more detailed anatomic description of the anterior visual pathway in NFMA patients compared to conventional MRI. - Assess the feasibility of high-field MRI to…
The overall aim is develop a rational dosing regimen of liposomal amphotericin B in obese patients. To achieve this goal we have defined the following objectives: Primary objective:* To determine the pharmacokinetics of liposomal amphotericin B…
Main objective:- To assess the tumor uptake of Zr89-labeled CER-001 (% injected dose/gram)Secondary objectives:- To evaluate the biodistribution of Z89r-labeled CER-001- To evaluate the correlation between Zr89-labeled CER-001 and tumor…
The aim of the study is to investigate the effect of magnetic resonance (MR) based online adaptive radiotherapy (RT) for treatment of low to intermediate risk localized prostate carcinoma (PCa) on the radiotherapy dose on the prostate and organs at…
This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week corticosteroid (CS) taper regimen compared to placebo in combination with a 52-week CS taper regimen, as measured…
Radiation-induced damage to the salivary glands of head-and-neck (H&N) cancer patients results in functional impairment and consequently in long-term toxicity, xerostomia or dry mouth. Long term, late toxicity deteriorates significantly the…
Primary Objectives: • To evaluate the subjective and objective cognitive complaints and cognitive function in patients receiving radiotherapy for their vestibular schwannoma. Secondary objectives:• To explore the use of (MRI) imaging biomarkers for…
We aim to assess the stability of the ocular structures and tantalum clips during the complete PBT treatment, so no part of the tumour is missed during radiotherapy, to reduce the total burden for the patient.