3 results
• To evaluate the tolerability and safety of ascending single oral doses of ACT-541468 in healthy male subjects.• To investigate the single oral dose pharmacokinetic (PK) and PD of ACT-541468 in healthy male subjects.• To investigate dose…
The study objectives are:- to characterize the biotransformation pathways, the routes and rates of excretion, and total recovery of the 14C-labeled research medication and its radiolabeled metabolites- to characterize the pharmacokinetics (PK) of…
In this pilot study we have technical/methodological questions: we want to confirm the envisioned kinetic profiles of stable isotope tracers 13C-labelled SCFA delivered by catheter in 5 subjects, and to establish the time points of plasma sampling (…