3 results
The purpose of the study is to investigate how quickly and to what extent diclophenac is absorbed and eliminated from the body (this is called pharmacokinetics) when it is administrated by using a HP-5000 transdermal patch. Furthermore, the…
The primary objective is:• To evaluate the safety and tolerability of a single local i.c. dose of SI-053 to establish the MTD and/or the RP2D (dose escalation) and to further evaluate safety at the RP2D (dose expansion).The secondary objective is:•…
Patients with ALS are routinely prescribed riluzole, the only registered drug for the treatment of ALS. This study will evaluate the concentration-effect relationship of riluzole (100 mg) and retigabine (300 mg) on axonal excitability measures. In…