2 results
Approved WMOCompleted
To compare the efficacy of a fixed dose of SC methylnaltrexone to induce laxation in patients receiving palliative care with constipation due to either fentanyl, oxycodone or morphine sulphate (opioids with different mechanisms of action). Secondary…
Approved WMOCompleted
To evaluate the inter- and intra-subject variability in pharmacokinetics (PK) and pharmacodynamics (PD) of study drug following a two-period repeated single dose of 2 mg delivered by subcutaneous (SC) injection in healthy volunteers.