7 results
To show in a prospective randomised study if intravitreal injection of Triamcinolonacetonide combined with Macula Grid Laser gives a better increase in visual acuity and/or decrease in macular edema than Macula Grid Laser combined with sub-Tenon…
Primary:To evaluate the efficacy of ruxolitinib cream in participants with vitiligo.Secondary:To further assess the efficacy of ruxolitinib cream.To evaluate the safety and tolerability of ruxolitinib cream.To evaluate the ruxolitinib PK in plasma…
Primary: To estimate the antitumor activity (assessed as overall response rate) of PDR001 as a single agent in patients with non-functional neuro-endocrine tumors (NET).Secondary: To estimate efficacy (duration of response) of PDR001. Safety and…
Primary: To characterize the safety and tolerability of PDR001 in combination with LCL161, everolimus, HDM201, QBM076 or panobinostat and to identify recommended doses and schedules for future studies.Secondary: To characterize changes in the immune…
* Safety Run inTo determine the recommended regimen of PDR001 in combination with dabrafenib and trametinib for the randomized part (part 3)* Biomarker cohortTo evaluate changes in the immune microenvironment and biomarker modulations upon treatment…
Primary Objective:To evaluate the duration of clinical response of ruxolitinib cream in participants with vitiligo.
To evaluate the efficacy of each combination arm, as measured by confirmed objective response rate (ORR)