10 results
The primary objective is to study whether treatment with the mTOR inhibitor Everolimus results in an objectable change in phosphorylation of the selected downstream effectors 4eBP1 and p70S6K in human prostate cancer biopsies. A secondary objective…
To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.
To assess the efficacy of two treatment strategies for fatigue and disabilities in QFS: long term treatment with doxycycline or cognitive behavioral therapy (CBT).
To assess the effect of low dose doxycycline on markers of neutrophilic inflammation and proteolytic activity stable GOLD III COPD patients.
In order to set up paradigms for pharmaco-MRI studies for development of novel psychotropic medications. The present study will investigate the effect of: - low-dose benzodiazepine on brain activation and test performance on a testbed of well…
To test whether 100 mg doxycycline inhibits aneurysm growth
To asses the short and long term effect on pain and function and the safety of doxycycline in patients with mild to severe pain due to established knee OA.
To determine the efficacy of antibiotic prophylaxis after a tick bite in the Dutch setting, in relation to tick infection, tick engorgement and attachment time.
In this study we want to assess the hepatic cyst penetration capacity of intravenously administered antibiotics (ciprofloxacin, co-trimoxazole, doxycycline and piperacillin/tazobactam) by comparing blood and cyst fluid concentrations in patients…
Investigate whether treatment with azithromycin has an inhibitory effect on the mTOR pathway and/or C. acnes, causing a reduction of the inflammatory activity which is found in sarcoidosis patients measured by blood biomarkers ACE and sIL-2R and by…