10 results
To compare the efficacy of two dose levels of erlotinib (150 mg and 300 mg) on progression-free survival (PFS) in current smokers with stage IIIB/IV NSCLC after failure of first-line platinum-based chemotherapy.
To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.
To assess the efficacy of two treatment strategies for fatigue and disabilities in QFS: long term treatment with doxycycline or cognitive behavioral therapy (CBT).
To assess the effect of low dose doxycycline on markers of neutrophilic inflammation and proteolytic activity stable GOLD III COPD patients.
To test whether 100 mg doxycycline inhibits aneurysm growth
To asses the short and long term effect on pain and function and the safety of doxycycline in patients with mild to severe pain due to established knee OA.
To determine the efficacy of antibiotic prophylaxis after a tick bite in the Dutch setting, in relation to tick infection, tick engorgement and attachment time.
In this study we want to assess the hepatic cyst penetration capacity of intravenously administered antibiotics (ciprofloxacin, co-trimoxazole, doxycycline and piperacillin/tazobactam) by comparing blood and cyst fluid concentrations in patients…
Primary Objectives* To assess the pharmacodynamic effects of systemic prednisolone on the LPS- or IMQ-induced inflammatory response* To assess safety & tolerability of intradermal LPS and topical IMQ in combination with prednisoloneSecondary…
Investigate whether treatment with azithromycin has an inhibitory effect on the mTOR pathway and/or C. acnes, causing a reduction of the inflammatory activity which is found in sarcoidosis patients measured by blood biomarkers ACE and sIL-2R and by…