25 results
Primary objective: To evaluate the safety and tolerability of GSK1795091 when administered in combination with either GSK3174998, GSK3359609, orpembrolizumab.Secondary objectives: * To evaluate the antitumor activity of GSK1795091 when administered…
In this functional Magnetic Resonance Imaging (fMRI) study, the primary objective is to examine the acute effects of intranasal OT administration on emotional- and reward-related brain processes in PTSD patients compared to traumatized healthy…
Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…
To evaluate the effects of intranasal oxytocin versus placebo on social behaviour and also on eating behaviour in children with PWS.
1. To evaluate the progression-free-survival (PFS) in patients with ipilimumab refractory advanced MEL receiving either MK-3475 or chemotherapy.2. To evaluate the overall survival (OS) in patients with ipilimumab refractory advanced MEL receiving…
Objectives: 1) To investigate whether attachment security, autonomy-connectedness, and childhood experiences moderate effects of social support during stress; 2) To investigate the influence of oxytocin on the ability to be close to others (in an…
Our primary objective is to investigate whether oxytocin administration can affect empathy and emotion recognition in healthy and antisocial adolescents. We expect that oxytocin will enhance empathy and emotion recognition in both healthy and…
Primary objectives:(1) To determine the safety and tolerability of pembrolizumab. (2) To evaluate the Overall Response Rate (ORR) of pembrolizumab by independent central review according to the International Working Group (IWG) response criteria (…
To determine if maintenance therapy with AZN will provide significant improvements in PCD lung disease, compared to placebo: reduction in respiratory system exacerbations and improvement in lung function, ventilation inhomogeneity, improvement in…
With the proposed study we aim to gain insight into the effects of oxytocin (OT) on both parents* and grandparents* sensitive, empathic, and protective responses to their (grand)children, and in the neural origins of these responses.The primary…
Our primary aims are 1) to test with observational and electrophysiological techniques whether intranasal oxytocin administration to mothers of young infants increases their defensive reactivity and protective approach responses in mildly…
Our study aims at investigating whether male adults with ASD differ from healthy male adults in their neurophysiological responses to positive and negative empathy-evoking pictures when taking oxytocin intranasally once. To this end we will compare…
In this study neural responses to infant crying will be measured with fMRI. In addition, the neural base of emotion understanding will be examined with fMRI. Participants will look at pictures of adults and infant and they have to infer the mental…
In this study we will assess these prosocial effects in an objective way i.e. by means of computer tasks and we will investigate the role of two potential mediators and the role of a genotype variant in the mechanism underlying prosocial behavior.…
- to assess the effects of intranasal administration of oxytocin in comparison to placebo on trust, as measured by the behavioural response to the Trust game- to assess the effects of intranasal administration of oxytocin in comparison to placebo on…
In this study we focus on behavior in response to different infant signals, including crying as well as smiling. More specifically we investigate the behavioral differences of an individual towards different infants who are either perceived as happy…
To study whether the administration of oxytocin leads to stronger empathic responses on 3 different empathy-related tasks compared to a placebo.
With the proposed study we want to gain insight into the neaural mechanisms underlying (the development of) shame-proneness and fear of failure. We want to investigate whether the administration of oxytocin modulates effects of love withdrawal and…
The proposed study has two objectives. First, we will examine the neural mechanisms of aversive responding to infant cries in healthy female subjects. We will compare participants who showed high cardiovascular responses to infant cries with…
This proposal centers on hormone-behavior dynamics in paternal caregiving, with the goal of gaining a better understanding of the development of human paternal caregiving. There is limited information on the hormonal basis of caregiving patterns in…