7 results
Primary Objective: To assess the effect of treatment with three doses of botulinum toxin type-A (Dysport®) versus placebo on the number of episodes of urgency and frequency of micturition experienced in continent female subjects with idiopathic…
To show that an individually tailored treatment of the calf muscles with BTX-A promotes the balance capacity and mobility of HSP patients by an effective reduction of spasticity while preserving muscle strength. This explorative study uses a pre-…
Objective: to determine whether botulinum toxin A (btA) injections, intensive bimanual skill training, or a combination of both leads to more and better use of the affected arm in hemiparetic children in play, leisure time, school and personal care.
1. A better understanding of the apraglutide dose/concentration-effect relationship;2. A better understanding of duration of effect (apraglutide kinetics in relation to citrulline kinetics).
Target Population:Subjects with urinary incontinence (UI) caused by neurogenic detrusor overactivity (NDO)due to either spinal cord injury (SCI) or multiple sclerosis (MS), who have not beenadequately managed with oral medication and who routinely…
In this study we will investigate how quickly and to what extend the approved compounds repaglinide, tolbutamide, midazolam or caffeine are absorbed and eliminated from the body when it is given together with PXL770. This study is a drug-drug…
Primary ObjectivesTo assess the effects of pexidartinib on the PK parameters of single-dose midazolam and tolbutamide in patients.Secondary ObjectivesTo evaluate:- To determine the overall response rate (ORR) in patients with TGCT,kit-mutant…