5 results
PrimaryTo assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of an OCT2 probe substrate, metformin, in healthy male subjects.To assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of a BCRP probe substrate,…
Primary objective: To test for the first time in a double-blind randomized, placebo controlled trial whether three years treatment with metformin 1000 mg bd added to titrated insulin therapy (towards target HbA1c 7.0%/ 53 mmol/mol) reduces…
Evaluate if ironabsorption is disturbed after a RYGB, which leads to a insufficient treatment of oral ironsuppletion. Analyse if failure of oral ironsuppletion is predictable at baseline (T=0) in the absorption test.
Treatment of overweight persons with insulinresistance with a low dose metformin added to yoghurt. The early reduction of glucose, especially the postprandial glucose will hopefully slow the process from insuline resistance to diabetes mellitus.…
This study is designed to investigate the limiting effect on infarct size of high dose intravenous adenosine during primary angioplasty