10 results
Primary Objective: To elucidate the effect of age on the UGT activities using the plasma paracetamol to APAP-glucuronide clearance after a simultaneous intravenous therapeutic dose and an oral microdose.Secondary Objectives:To determine the effect…
To determine the efficacy of antibiotic prophylaxis after a tick bite in the Dutch setting, in relation to tick infection, tick engorgement and attachment time.
In this study we want to assess the hepatic cyst penetration capacity of intravenously administered antibiotics (ciprofloxacin, co-trimoxazole, doxycycline and piperacillin/tazobactam) by comparing blood and cyst fluid concentrations in patients…
To assess the effect of low dose doxycycline on markers of neutrophilic inflammation and proteolytic activity stable GOLD III COPD patients.
To test whether 100 mg doxycycline inhibits aneurysm growth
To assess the efficacy of two treatment strategies for fatigue and disabilities in QFS: long term treatment with doxycycline or cognitive behavioral therapy (CBT).
To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.
Primary:to assess the glycemic effects of a single dose of OXM on the ambient glucose levels during a GGI assessmentto assess the insulinotropic effects of a single dose of OXM measured as a change in "*" during a GGI assessmentSecondary:…
To asses the short and long term effect on pain and function and the safety of doxycycline in patients with mild to severe pain due to established knee OA.
Investigate whether treatment with azithromycin has an inhibitory effect on the mTOR pathway and/or C. acnes, causing a reduction of the inflammatory activity which is found in sarcoidosis patients measured by blood biomarkers ACE and sIL-2R and by…