23 results
Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.
- Six weeks of ESM combined with personalized feedback sessions, compared with treatment as usual (TAU), leads to a stronger reduction in fatigue symptoms (primary outcome clinical effectiveness). - This intervention also leads to improvements in…
Adequate perfusion of an adult-sized renal graft in children demands significant hemodynamic changes after transplantation (Tx). Suboptimal renal graft perfusion due to inadequate hemodynamic adaptation increases the risk of loss of renal graft mass…
To assess the PK/PD relationship of prednisolone as either prophylaxis or therapy of GVHD in children after HCT.
To evaluate the effectiveness of eccentric calf muscle exercise therapy compared to strength training of the upper extremities (control group) in patients with chronic midportion Achilles tendinopathy.
This study will evaluate if a pre-colonoscopy consultation at the outpatient clinic can be replaced by an eHealth tool for FIT positive participants who are referred for colonoscopy.
The primary objective of this study is to evaluate the effect of surgical correction of pes equinovarus deformity compared to conservative treatment on personalized goal attainment. In addition, we will evaluate the effect of surgical correction of…
Primary Objective: 1. What is the difference in effectiveness of Early Time-restricted Eating (eTRE) in glycaemic regulation when compared to isocaloric continues caloric restriction (CCR) after one year in overweight adults with type 2 diabetes?…
Vapor ablation can effectively and safely eradicate short BE segments
1) the OST is superior to the 3-weeks waiting period 2) the OST+app is superior to the OST-only at post-treatment and at follow-up
Action research in which the intervention will be developped trough short-cylce evaluation rounds by the research team together with an expert panel. The initital intervention has been designed based on scientific literature review, practical…
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene expansion carriers on negative medication effects of HD-related medication with an actionable drug-gene interaction in the…
The main objective is to study the effect of a nutritional intervention on white matter integrity at the corrected age of three months in infants born at a gestational age <30+0 weeks. Secondary objectives of the study are to determine the…
As changes in gutmicrobiota composition could play a role in the development of autoimmune diseases including hypothyroidism, we will investigate whether repetitive fecal transplantation from either allogenic (healthy) or autologous (own) fecal…
We hypothesized that intensive GDM treatment according to the new (2013) GDM criteria would result in a reduction in infants with birth weight >90th centile (large for gestational age, LGA), in comparison to treatment according to the old…
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
Bone-anchored maxillary protraction therapy improves facial profile in cleft children.
PENG block with phenol provides better pain relieve and mobility, and therefore quality of life, compared to current pain relieve strategies in patients with a hipfracture who are not eligible for surgery
PCT-guided treatment regarding antibiotic use is non-inferior to usual care consisting of prednisolone and or antibiotics, in terms of treatment failure at day 30 for patients hospitalized because of an acute exacerbation of COPD (AECOPD).
It is hypothesized that bCBT for severe fatigue will lead to clinical improvements in fatigue levels compared to usual care.