31 results
To compare gastrointestinal digestion (gastric emptying and postprandial amino acids dynamics) between two dairy-based drinks containing casein and matched on macronutrient composition but differing in mineral composition.
There might be discrepancies in number and type of Cancer Predisposition Syndrome diagnoses between the genotype first and the phenotype first approach.
Critical illness, along with the lack of zeitgebers on the PICU environment, and iatrogenic influences like medication and procedures, results in disturbed circadian rhythms in critically ill children, which is important for their recovery.
Vapor ablation can effectively and safely eradicate short BE segments
To assess the PK/PD relationship of prednisolone as either prophylaxis or therapy of GVHD in children after HCT.
Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.
The objective of the PANDORINA trial is to evaluate the non-inferiority of omitting routine intra-abdominal drainage after DP on postoperative morbidity (Clavien-Dindo score ≥ 3), and, secondarily, POPF grade B/C.
Extracellular vesicles (EVs) in plasma can be used as a biomarker for stroke diagnosis, thereby discriminating between ischemic and hemorrhagic stroke.
Primary Objective: To investigate whether timely delivery of iCBT will lead to a significantly lower mean fatigue severity score (CIS-fatigue) across follow-up visits (T1 and T2) as compared to care as usual. Secondary Objectives: To investigate…
Our hypothesis is that macrophages drive ANCA glomerulonephritis by activating T-cells and enhancing their migration towards vasculitic inflammation. Permanent macrophage activation could contribute to chronic elevation of fatigue levels.
the application of EMDR therapy is associated with a significant decrease in severity of depressive symptoms and decrease of percentage of patients meeting DSM-5 criteria for MDD compared to the waiting list. Participants receiving EMDR report after…
Is a 6-month PRET program effective in reducing CVRF diabetes mellitus type 2(HbA1c FG), in adults with mild to moderate ID. Secondary Objective(s): Is a 6-month PRET program effective in reducing other CVRF: hypertension (SBP, DBP),…
Colchicine admission attenuates inflammatory response of monocytes and neutrophils stimulated with MSU crystals, isolated from patients with chronic coronary artery disease after colchicine 0.5mg daily during one month, compared to placebo
We hypothesize that the inter-observer variability of the CPR, MCA, UA and UtA measurement will be less than intra-observer variability due to normal biological variation of cardiovascular control.
The present study aims to evaluate efficacy and feasibility of an online group intervention for parents of children with cancer that focuses on the specific issues that play a role in parents coping with a child with cancer. Hypothesis: Participants…
1) To investigate the effect of either the consumption of 1 or 3 small meals compared to no meal during the night shift on alertness levels, gastrointestinal complaints and glucose levels. 2) To investigate the effect of low glycaemic loaded meal(s…
The main objective of the study is to assess the change in first morning void urine albumin-to-creatinine ratio across the study period. The secondary objective is to assess changes from baseline in systolic blood pressure, body weight, eGFR and…
To determine which patients, individually classified for VTE ánd bleeding risk, will benefit from prolonged anticoagulant treatment without being unnecessarily exposed to its risks.
In this study we would like to investigate the clinical effectiveness of a smart technology intervention (The Heart Failure Box) in heart failure patients from the department of Cardiology at Leiden University Medical Center.
It is hypothesized that bCBT for severe fatigue will lead to clinical improvements in fatigue levels compared to usual care.