466 results
Main objective: To evaluate the pain reduction in patients receiving Instanyl®Secondary objectives: To evaluate; the duration of pain reduction in patients receiving Instanyl®; the degree of adverse effects in patients receiving Instanyl®: whether…
The primary objective of this study is to assess the effect of individualizing the growth hormone dose versus standard treatment with 1 mg/m2/day on adult height. Secondly, we want to assess the first and five year growth response, the long term…
To determine the efficacy and safety of abatacept SC in rheumatoid arthritis patients in daily clinical practice over 24 months. In addition, the retention rate of abatacept SC will be assessed during this study.
Primairy objective:- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks, measured by laser Doppler imaging, in SSc subjects with an early or active SSc pattern, measured with nailfold capillaroscopy (NFM), with…
In the proposed study, two main issues will be addressed: first, it will be studied whether a high dose (4.0 mg) of FA supplementation periconceptional has an added value over the now recommended low dose of 0.4 mg in the prevention of congenital…
The primary objective of this study is to provide an updated pharmacokinetic profile of orally administered nitrofurantoin in women aged 55 to 75 years.
Primary Objective: test the feasibility of Dynamic-CE-MRI using Ablavar ® as contrast agent to detect peritoneal endometriosis in women.Secondary Objective(s): # To assess the image quality of Ablavar ®-enhanced MRI in comparison to unenhanced MRI…
The objective of this study is to investigate the added effect of an intramuscular (IM) gluteal corticosteroid injection above a placebo IM gluteal injection (saline) on pain symptoms in patients with hip OA, not responding satisfactory to the usual…
The primary objective of this investigation is to evaluate the performance of the DISCOVER Artificial CervicalDisc in the treatment of cervical disc disease by measuring the function assessed via Neck Disability Index(NDI) and neurological function…
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
Primary:Is the degree of pupildilation, achieved after administrating a 4.5 microliter microdrop tropicamide 0.5% equivalent to the pupildilation after a regular 30 microliter eydrop tropicamide 0.5% in healthy volunteers?Secondary: Is there a…
To investigate the use of a temporary peginterferon alpha-2a add-on strategy during entecavir therapy in patients with HBeAg-positive chronic hepatitis B by comparing the efficacy of this regimen versus entecavir monotherapy.To evaluate the long-…
To study whether dipyridamole reduces gastrointestinal absorption of metformin.
Primary Objective: to compare the atrial contractility by means of echocardiography between patients receiving flecainide and vernakalant i.v. after conversion to sinus rhythmSecondary Objective(s): 2a. To compare the conversion rate of AF between…
The primary objective is to test the hypothesis that, after at least 15 weeks of daily administration (4 for titration, 7 of relatively stable dose, 4 at fixed doses; Study Period II), risperidone given orally in a dose of 0.25 - 3.0 mg/d depending…
Comparison of the accuracy of achieved correction of the mechanical axis in the frontal plane relative to preoperative planning, endeavouring to achieve an overcorrection of a varus malalignment to 3-4° of valgus, comparing open and closed HTO*s.
The 1st main objective is to collect detailed quantitative data on the everyday management of mRCC in the Netherlands, the clinical outcome of this management, as well as the resulting quality of life and financial costs. Treatment selection for…
Primary objectives* To evaluate the initial and long-term clinical results in terms of function, quality of life and pain/satisfaction of the Signature* procedure compared to the standard operation instruments (Vanguard CR cemented fixation).* To…
To identify what might be the cause of the occurrence of diarrhea during the use of angiogenesis inhibitors sunitinib and sorafenib in patients with a malignancy.
What is the function of the forearm after a torus fracture in children at an age of 4 to 10 with different immobilisation techniquesWhat is the time that children after a torus fracture are using their limb, without making use of a form of…