24 results
This study will establish the role of surgical versus nonsurgical approaches in patients whose melanoma has spread to distant sites. Results will help clinicians develop a standardized initial approach that prolongs survival and optimizes quality of…
To collect data on knee joint replacement procedures or procedurespracticed in the knee (arthroscopy, osteotomy or other) over 5 years inpatients with knee osteoarthritis having participated in the CL3-12911-018 study and having received at least…
Safety-evaluation in case of long term daily usage of MPC-7869. In this Open Label Study , with regard to the safety of MPC-7869, attention will be paid to the amount of AE*s, the physical examinations of subjects, the research of vital functions,…
The purpose of this study is to monitor whether preicncisional bupivacaine (bupivacaïne 0,5% with epinefrine 1:200.000), infiltration in trocarcincisions reduces postoperative wound pain in patients undergoing laparoscopic cholecystectomy.
The purpose of this study is to monitor whether preicncisional bupivacaine (bupivacaïne 0,5% with epinefrine 1:200.000), infiltration in trocarcincisions reduces postoperative wound pain.
The objective of this study is to determine the prevalence of xerostomia after radiotherapy of oropharyngeal tumors when sparing the parotid glands and one submandibular gland.
To determin the effect of low dose azithromycin ( 3 times a week 250 mg) on the cough related health status in patients with COPD and chronic productive cough.In a randomized controlled study.
• to assess opioid-induced constipation based on Complete Spontaneous Bowel Movement (CSBMs) recorded in the subject daily diaries during the first 4 weeks of the Double-blind Phase.• to assess the frequency of laxative use during the 12 weeks of…
This study aims at evaluating whether indocyanin green (ICG) enhanced intra-operative near-infrared fluorescence (NIRF) imaging is as good as or even better than the standard technique (technetium-99 labeled colloid and Patent Blue) in detecting…
To prospectively study if patients carrying clinically relevant DPYD variants (DPYD*2A, c.2846A>T, c.1236G>A/HapB3, c.1679T>G) are more at risk for developing moderate/severe vesicles or bullae with 5-FU cream.
The primary objectives of this study are to:• Evaluate the incidence and severity of late-onset targeted adverse events (AEs)/serious adverse events (SAEs) suspected to be possibly related to gene-modified cells, including neurologic disorders,…
To identify molecular biomarker profiles that are associated with cervical tumorigenesis, and that can be used for development of an algorithm for detection of low grade CIN1, CIN2, CIN3 and cervical cancer. The algorithm should provide advice for a…
The purpose of this study is to evaluate the effect of low-load BFR therapy on quadriceps and hamstring strength 8-, 14-, 26-, 39- and 52-weeks after BPTB ACL reconstruction compared to placebo BFR therapy and conventional HLR training.
To evaluate the perioperative hemostatic efficacy of BAX 802 in male subjects with CHA with inhibitors to human factor VIII (hFVIII) undergoing major or minor elective surgical, dental, or other invasive procedures as determined by the Global…
Study Rationale and ObjectivesThe objective of the study is to determine the efficacy and safety of lacosamide, a sodium channel blocker, in patients with pain due to SCN9A-associated SFN. The proposed study plans to recruit patients with clinically…
This study aims to provide evidence for the notion that reduction of spasticity by bilateral BTX injections in the hip adductor group followed by self-administered stretching exercises and agility training improves lateral stepping and gait…
The objective of the clinical study is to evaluate the incidence of device- and procedure-related safety, efficacy, and efficiency (6-and 12-month outcomes) when using the AcQMap as an imaging and mapping system for ablation of persistent atrial…
Safety: To provide confirmatory evidence that use of the LIFT System, inclusive of all components and accessories, is safe.Effectiveness: To provide confirmatory evidence that use of the LIFT System provides an effective treatment for the…
The primary objective is to evaluate the effectivity of frozen gloves during chemotherapy in the prevention of neurotoxicity and thereby the influence on the quality of life in patients treated with oxaliplatin, paclitaxel or docetaxel.
To provide, or continue to provide, UT-15C SR for eligible subjects who participated in protocols TDE-PH-301 or TDE-PH-302 or TDE-PH-308 or additional UC-15C SR clinical protocols.To assess the long-term safety of UT-15C SR in these subjects through…