48 results
The primary aim of this study is to determine whether the biomarkers PCA3, TMPRSS2-ERG and the NovioGendix prostate cancer biomarker panel (NGMP) are, by themselves or as a panel of biomarkers, a reliable predictor of survival in men with CRPC…
Question: Is it an added value for the patient if there will be a default capsaicin provocation test to diagnose chronic cough?It will be investigated or with the aid of the capsaicin provocation test the diagnosis sensory hyperreactivity (SHR) can…
Primary objective We investigate whether observers* inferring accuracy differs when the consumer is in the presence of a friend compared to being completely alone. We test whether observers* brain activations during inferring observation differ…
1. The primary aim of the proposed research is to compare the value of current best available imaging method (PET-CT) with recently evolved functional imaging with DWI-MRI alone or in combination with PET/CT in determining response to neo-adjuvant…
To guide the analgesic component of anesthesia using the Nociceptive Level (NoL) index in ASA 1-3 patients under general anesthesia for elective abdominal surgery.
The aim of this study is to explore whether subjectively experienced SB can be objectively assessed using computerized vision based analysis of motor performance upon awakening. Secondarily, patient experiences and data quality of the assessment…
Primary:• In this project, we propose to study the use of this aspiration fluid from the intraperitoneal cavity as a biomarker for the efficacy of chemotherapy intervention.The research questions for this study are:• Monitor the effect of…
The main objective of this phase II observational study is to investigate the early and early-delayed toxicity in 100 patients with localized prostate cancer (cT1c-T3bN0M0) that is observed in the first year following after stereotactic MRI-guided…
To address the hypothesis that a potato derived protease inhibitor cream significantly limits perianal dermatitis in patients after colorectal surgery.
Examining the hypothesis that patients with ACL deficiency and patients with ACL reconstructions, despite comparable force-reproduction capacities with the affected, dominant right leg, have a significant altered EEG Theta-activity in the motor…
This Phase II trial aims to:1 Test the predictive value of Zr89 Cetuximab uptake in vivo for treatment specific outcome 2 Explore the impact of dose redistribution on loco-regional control and disease free survival.If individualized treatment…
Primary Objectives:• show effectiveness of the SMSC instrument in 3D correction of the spine prior to placement of the implants.The hypothesis is that to achieve de-rotation of the spine without failure of the pedicle screws, de-rotation has to be…
The primary objective of this study is to test safety and performance of the APD Perfusion Measurement Catheter & Monitor for the measurement of gut perfusion in humans. The secondary objectives of this study are to assess the normal values…
Our aim is to determine a Pharmacokinetic/Pharmacodynamic (PkPd) based dosing model for nicardipine used for treatment of severe hypertension in preeclamptic patients. The model is based upon determination of maternal, fetal and neonatal plasma…
To evaluate the accuracy and adverse events of combined use of minimal invasive optical coherence tomography (OCT) to differentiate normal tissue from (different types of) malignant tissue in kidneys.
The aim of this study if PET using [18F] fluorothymidine (FLT), an imaging biomarker, performed at week 10 of concomitant radio/chemotherapy for patients with newly diagnosed GBM is superior to MRI at 10 weeks to evaluate treatment response and to…
The primary aim of ICT4D is to design an intelligent monitoring and selfhelpsystem for use in Primary Care (Moodbuster). In this pilot study the feasibility and the usability if this intervention is tested among patients suffering from minor and…
To objectify the effect of the VLS-system during daily use regarding postural stability and quality of life.
The primary objective of this study is to evaluate the ability of PET-MRI to detect LSR during the first year of follow-up after RFA treatment of CRLM as compared with ceCT and PET-CT. Standard reference will be histology (when available) or…
1 to describe the long term effects of FGT and mutual support among first-degree relatives and spouses of suicide victims.2 inventarisation of help seeking behaviour of first-degree relatives and spouses of suicide victims during the first year…