32 results
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
To assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer*s disease-causing mutation by determining if treatment with the study drug slows the rate of progression…
Primary objectives: - To evaluate the toxicity and feasibility of a preemptive minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination.- To evaluate the effect of a minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination on…
To study the effect size of FMT after a 3 weeks course of budesonide as induction therapy in patients with active ulcerative colitis despite previous therapy. The purpose of the pre-treatment is to reduce active inflammation prior to donor feces…
To evaluate the effectiveness of a multidisciplinary outpatient group-based nutrition and lifestyle intervention program *Reverse diabetes type 2* executed by Voeding Leeft on self-reported haemoglobin A1c (Hb1Ac) as measure of glucose regulation…
The primary aim of this first line 177Lu-PSMA RLT study is to evaluate the clinical efficacy in castration resistant metastatic prostate cancer. Secondary aims are to assess the progression free survival (radiographic, clinical or PSA progression…
This study investigates the safety and tolerability of deferoxamine use in patients with aneurysma subarachnoid hemorrhage.
The overall aim of this study is to identify developmental deficits in children with Rolandic epilepsy. If developmental deficits are observed, we hope to determine timing, persistence, and prognostic factors for developmental deficits and improve…
To asses the hypothesis that chronic postoperative inguinal pain occurs less in patients treated with the TREPP technique
Objective:The objective of the study is to test the hypothesis that the QWHET micro current wound stimulation device has minimal side effects. The study will be designed as a double blind, prospective study.The results will be used to obtain a CE…
1.3. Study Design Rationale The ATLAS-PPX trial (ALN-AT3SC-009) is a multicenter, multinational, open-label Phase 3 switching study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B, with inhibitory…
The objective of this study is to evaluate blood pressure response after renal denervation in patients with uncontrolled hypertension compared to a sham-controlled population, in the absence of antihypertensive medications. In this study, *…
The aim of this research is to investigate whether it is feasible and safe to treat operated pancreatic cancer patients who have completed standard of care treatment with dendritic cell immunotherapy using dendritic cells loaded with autologous…
The effect of pelvic floor physiotherapy with biofeedback in patients with anal fissure and pelvic floor dysfunction.
Primary objective: Does removal of an IUC late at night on the day of vaginal prolapse surgery lead to a decrease in clinical UTIs in the first six weeks after surgery compared to removal on the morning of the first day after surgery?Secondary…
To investigate whethere there is a difference in gastric emptying (emptying half-time t50) after ingestion of cow milk between lactose tolerant, habitual milk consumers reporting no gastro-intestinal symptoms and non-habitual milk consumers…
The primary objective of this study is to show equivalence of the total pathological complete response rate (tpCR) in patients treated withHD201 plus chemotherapy to that in patients treated with Herceptin® plus chemotherapy. tpCR will be assessed…
To determine the safety of the MobiusHD System and the efficacy of the MobiusHD device in lowering mean systolic 24-hour ambulatory blood pressure in subjects with resistant hypertension. The hypothesis is that mean systolic 24-hour ambulatory blood…
The primary objective is to measure the level of clinical improvement and quality of life at 6, 12 and 18 months. The secondary objective is to measure functional repair using MRI at 6 and 18 months postoperative. Other important objectives are…
The primary objective of this study is to evaluate the proportion of patients achieving FXI inhibition * 80% at trough (Day 91) after monthly dosing at 3 dose levels of MAA868.