19 results
1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10. This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…
A decrease in the incidence of central line-associated bloodstream infections in the investigational study group, compared to the control group.
PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancer SECONDARY OBJECTIVES: To assess in children with cancer after SARS-CoV 2 vaccination: - durability of…
The aim of our descriptive study was to quantify the disease burden leading to hospital-based care, repatriation or death in Dutch travelers during their stay in a foreign country, including Europe. The outcome of this study could be used as…
The two objectives of this study are: 1) validation of two questionnaires, the Misophonia Screening List - Child and Youth and the Amsterdam Misophonia Scale-Youth (AMISOS-Y), in order to screen adequately for misophonia 2) testing the effectiveness…
The effect of mebeverine on abdominal pain intensity and frequency in children with irritable bowel syndrome or functional abdominal pain – not otherwise specified will be effective.
Primary Objectives: -To evaluate if the treatment of Low Risk HB can be reduced (Group B1) -To compare different induction treatment regimens for Intermediate risk HB (Group C) -To compare different post induction treatment regimens for…
This multicentre randomised controlled trial aims to investigate whether PoCUS can be used as an adjunct to improve first attempt success rate in closed reductions of displaced distal radial fractures in adults in the ED.
The objectives are firstly that Love is... promotes the healthy sexual development by increasing knowledge and positive attitudes towards sexuality. Secondly, characteristics of adolescents who do not improve from the general prevention program are…
To establish the diagnostisch accuracy of ultrasound for the exclusion of fracture of the elbow
Primary objectives: - Overall: Improvement of event-free survival (EFS) probabilities in childhood relapsed ALL - Randomization 1: EFS of Arm A (ALL-REZ BFM 2002) versus B (ALLR3) in SR patients - Randomization 2: Influence of epratuzumab…
Objectives: 1) to evaluate the effectiveness of the e-CBT-i “i-Sleep” compared to a waiting list condition on sleep efficiency at 3, 6 and 12 months in ACC. 2) to assess the effects of eCBT-I on secondary outcomes: fatigue, quality of life, chronic…
the application of EMDR therapy is associated with a significant decrease in severity of depressive symptoms and decrease of percentage of patients meeting DSM-5 criteria for MDD compared to the waiting list. Participants receiving EMDR report after…
To analyze the number of patients with (germline/somatic) actionable molecular aberrations in patients with relapsed/refractory pediatric tumors for whom no standard treatment or study protocol is available.
Virtual reality hypnosis is similarly effective in comparison to conventional medical hypnosis in reduction of pain and anxiety throughout needle related procedures in children in a clinical setting.
Bone-anchored maxillary protraction therapy improves facial profile in cleft children.
Adequate perfusion of an adult-sized renal graft in children demands significant hemodynamic changes after transplantation (Tx). Suboptimal renal graft perfusion due to inadequate hemodynamic adaptation increases the risk of loss of renal graft mass…