237 results
Information-processing: 1. Changes in measures of severity of OCD are explained (partially) by changes in measures of meta-cognitions (explicit and/or implicit); 2. Changes in measures of meta-cognitions (explicit and implicit) precede changes in…
To compare the efficacy of maintenance therapy with an equal monthly dose of imiglucerase when administered at a frequency of once every four weeks versus once every one or two weeks, in adult type I Gaucher disease patients in stable and good…
It is hypothesized that long term disabled persons who participate in the MDR program will return to work and have less mental and/or physical limitations to prevent te pre-disability income. Furthermore an explorative study into the process…
Our hypothesis is that peroperative fluid restriction will lead to a significant reduction of solid phase gastric emptying time ¨C measured by radionuclide scintigraphy-, and a reduction in its related postoperative complications.
1a. Changes in outcome measures of anxiety can be partly explained by changes in self-reported thougths; 1b. Changes in outcome measures of anxiety can be partly explained by changes in selective attention and by changes in fear relevant cognitive…
A more gradual training program for novice runners, will result in a reduction of running related injuries in novice runners.
Rituximab treatment leads to a decrease in synovial B cells. The clinical response is related to the decrease in synovial B cell numbers.
The primary aim of the study is: 1. To assess the role of an early intensification of two "AML" induction blocks versus protocol Ib directly after induction, in a randomized way in MR and HR patients. Secondary aims are: 2. To assess the…
Imiquimod, an immunomodulator, has been shown safe and effective in the treatment of external genital warts caused by low risk human papillomavirus (HPV). Therefore, it is hypothesized that this topical treatment may also be effective against…
The collaborative care approach is expected to be more effective and more cost-effective compared to care as usual.
(stress-sensitive) Patients with functional dyspepsia have a change in the dopaminergic system, through chronic stress, what leads to visceral hypersensitivity and therefore dyspeptic symptoms.
DBS in the nucleus accumbens can lead to long-term improvement of obsessive-compulsive symptoms and funtioning, without unacceptable side-effects.
Cognitive behaviour therapy and Self-examination therapy are both more effective in reducing depressive complaints than a waiting list control group.
A peptide representing the first eleven residues of hLF (hLF1-11) was shown to be effective in killing a variety of bacteria in vivo. The objective is to develop hLF1-11 as an effective and safe antibacterial and antifungal for the treatment of…
The aim of the study is: 1. To investigate the benefits and risks of hormonal substitution after prophylactic adnectomy in women with an increased risk for breast- and/or ovarian cancer due to a genetic predisposition; 2. To compare the effects and…
In the RIO study programme, the efficacy of rimonabant was examined. The next step is to assess the use of rimonabant, its safety and effectiveness in daily practice. In daily practice people also have other diseases, may use other medication and…
Several open-label pilot studies have shown a promising effect of intrapyloric botulinum toxin injection on symptoms in severe gastroparesis. However, data from randomized, double-blind, placebo-controlled studies are not yet available. We intend to…
Heart rate variability measures correlate with pain intensity in patients with advanced cancer.
The on-line intervention will prove to be significantly more effective in improving mood and reducing diabetes-related distress in diabetes patients with minor to moderately severe depression compared to the control condition (CAU, supplementend…