9 results
1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10. This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…
To prospectively study if patients carrying clinically relevant DPYD variants (DPYD*2A, c.2846A>T, c.1236G>A/HapB3, c.1679T>G) are more at risk for developing moderate/severe vesicles or bullae with 5-FU cream.
Continuous Intrajejunal Levodopa Infusion is not cost-effective compared to Deep Brain Stimulation
Treatment with Venoruton prevents RVO, which is a surrogate outcome of PTS.
Local antimycotic treatment of fungal toenail infection is more effective than placebo
Primary Objectives: -To evaluate if the treatment of Low Risk HB can be reduced (Group B1) -To compare different induction treatment regimens for Intermediate risk HB (Group C) -To compare different post induction treatment regimens for…
In rheumatoid arthritis (RA) patients with insufficient response to disease modifying anti-rheumatic drugs (DMARDs) it is unknown whether addition of tocilizumab (TCZ) to conventional synthetic (cs) DMARDs has superior efficacy compared to addition…
Primary Objective: - Achieving an event-free survival, which is not inferior to the ML-DS 2006 trial (87±3%) Secondary Objective(s): - Reduction of toxicity: severe adverse events (CTCAE v4.0 grade III or higher) - Evaluation of…
A serious game for wrist rehabilitation will be more effective at improving functional outcomes, pain scores and range of motion, compared to standard treatment regimens either or not including physiotherapy.