21306 results
To determine whether a strategy of invasive treatment (relative to continued medical treatment) of patients with type 2 diabetes mellitus, mild symptoms of stable angina pectoris, and documented myocardial ischemia lead to a decrease in cardiac…
To test the effectiveness of a self help booklet without therapist guidance vis-à-vis a psycho-education brochure for adult problem drinkers in the general population.
A 10% point difference between the intervention group and control group in IDM is expected. The sample size calculation is based on a worst-case scenario with regard to precision. For a binomial distribution, the widest distribution and thus largest…
It is expected that the CFS patient gets more insight in his or her physical activity pattern, intentions develops to change the behaviour, and really changes the behaviour resulting in a reduction of the CFS complaints.
"The primary objective of this study is to evaluate the fixation and migration patterns of the Persona Partial Knee (Zimmer Biomet, Warsaw, IN) in vivo, using model-based radiostereophotogrammetric (mRSA) analysis. The secondary objective is to…
The hypothesis is that patients with low anti-TNF drug levels have a higher risk of loss-of-response to anti-TNF drugs compared to patients with high anti-TNF drug levels.
1) The checklist 'Attune & Stimulate' is a valid instrument to assess the arousal level of clients with SID. 2) Caregivers who are randomized to the intervention group that is instructed to use the A&S-checklist attune…
Does suppletion of vitamine D3 (cholecalciferol) have an effect on the systolic blood pressure in hypertensive, vitamin D insufficient patients? 1. H0 hypothesis: there is no effect on the systolic blood pressure; 2. H1 hypothesis: the systolic…
We hypothesise that an anti-inflammatory dietary pattern (AIDP) has a beneficial effect on gut microbiome (diversity and permeability), thereby improving global functioning (measured with Outcome Questionnaire 45, OQ-45), and health of patients with…
A single PRP injection result in a clinical relevant reduction of the complaints at six months, compared to an injection with saline.
To study the effect of the interaction of cyclooxygenase-2 (COX-2) inhibition (started preoperatively and continued 5 days into the postoperative period) and extended local anaesthetic blockade via paravertebral block on postoperative central…
We hypothesize that an evidence based diagnostic algorithm, using fewer and preferably the least invasive diagnostic modalities can approach the accuracy of the complete panel of diagnostic tests.
We expect that the development of mitochondrial dysfunction lags behind the development of the hypermetabolic inflammatory state. Additionally, we hypothesize that the aggravation of factors related to the hypermetabolic inflammatory status, such as…
Breast cancer is the most common type of female cancer worldwide. Early detection has proven to have a positive influence on the prognosis and survival rate. An important aid in the detection and diagnosis of breast cancer is the use of medical…
Nonsimultaneous current steered pulse trains will lead to a single pitch percept whilst reducing the amount of current in comparison to conventional monopolar stimulation
We hypothesize that medical nutrition (PN and EN) compared with no medical nutrition (only oral nutrition) will be associated with better maintenance of nutritional status (fat- and fat free (muscle) mass and body weight), functional capacity,…
Non-inferiority (defined as < 12.5% increase) of pooled buffy coat-derived PR platelet concentrates (PR-plasma-PCs) compared to plasma (plasma-PCs) in terms of clinical efficacy determined by WHO grade ≥ 2 bleeding complications.
Background: Multiproblem young adults (between ages 18 and 27), characterized by a variety of severe psychosocial problems, comprise a societal challenge with high priority on the political agenda, both nationally and internationally. However, so…
Primary hypothesis: Octane concentrations in exhaled breath facilitate early detection of ARDS in ICU patients. Secondary hypotheses: - ARDS resolution is associated with a decrease in octane in exhaled breath. - Additional biomarkers of ARDS can be…