1633 results
To determine the difference in functional outcome between open reduction and internal platefixation and closed reduction and plaster immobilisation in patients with displaced complete articular distal radius fractures.
The primary objective of this study is to determine if the binding of [11C]PK11195, as a measure of neuroinflammation, in schizophrenic patients is decreased after simvastatin treatment.
The primary objective is to compare the amount, type and localisation of AGEs of the arterial wall of PAD, AAA and PAD+AAA in patients with and without diabetes mellitus.The secondary objectives are to explore the association between AGEs content of…
To assess and compare efficacy (complete response [CR] rate and overall survival [OS]) between SGI-110 and TC in adults with previously untreated AML who are not considered candidates for intensive remission induction chemotherapy.
Objective: Gather data on the use of Simband, positioned at the wrist, to estimate BP based on data from Simband*s ECG and PPG sensors, compare these results to the existing cuff-based BP measurements during haemodialysis treatment and apply the…
This is a phase III, open-label, multicenter, randomized study to investigate the efficacy and safety of atezolizumab (anti PDL1 antibody) compared with chemotherapy in patients with locally advanced or metastatic urothelial bladder cancer after…
This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.
This study aims to determine whether the ILC populations differ in the lungs of COPD patients, who differ with respect to COPD severity, and healthy subjects and how these cells are regulated by bronchial epithelial cells. Furthermore we want to…
Objective: to determine the underlying mechanisms and molecular events leading to remission of asthma.
The aim of the study is to evaluate the effect of MCP in acutely decompensated HF with the primary objective being its effect on the cumulative amount of diuretics needed and the length of the hospital stay due to decompenstaed heart failure .…
To evaluate the efficacy, safety, pharmacology, and patient-reported outcomes of the combination of taselisib plus fulvestrant compared to placebo plus fulvestrant in ER+, HER2- postmenopausal women with locally advanced or MBC and who have had…
(1) To evaluate the abilities of implanted adolescents to learn a second language in the current school settings compared to normal-hearing and hearing-impaired peers; (2) To identify and quantify environmental, sensory and cognitive aspects that…
This study is a Phase III, randomised, open label, multi-centre study assessing the efficacy and safety of MEDI4736 versus Standard of Care in NSCLC patients with PD-L1-positive tumours and the combination of MEDI4736 plus tremelimumab (MEDI4736+…
To gain insight in clinical, virological and immunological mechanisms and predictors of the eradication of HIV. To gain insight in the dynamics of the T cell HIV reservoir in which HIV is persisting. To gain insight in different levels of immune…
Primary: Time to first occurrence of MACE (cardiovascular death, myocardial infarction, or stroke) [Non-inferiority].Secondary: Time to first occurrence of MACE [Superiority], MACE or urgent revascularization for unstable angina, individual…
The primary objective of the phase II is to determine the progression free survival (PFS) at 1 year according to the RECIST 1.1 of the combination of pazopanib with weekly paclitaxel and carboplatin in platinum-resistant ovarian, fallopian tube or…
Primary Objective: The main objective of this study is to identify a new treatment to alleviate pain and diminish inflammation in patients with hand osteoarthritis with symptoms and signs of inflammation.Secondary Objectives: The secondary…
Primary: 1. To determine the MTD and/or RDE of the combination ceritinib and nivolumab. 2. To assess the preliminary antitumor activity of the combination.Secondary: 1: To assess the safety profile of the ceritinib and nivolumab combination. 2: To…
The main objective is to examine if 68Ga-exendin tracer accumulation (i.e. beta cell mass) differs in patients with persisting HH after RYGB compared to matched patients without HH after RYGB. The secondary objectives are:- compare GLP1 and GIP…