1776 results
Part 1 of the trial (already completed):The primary objective of the research concerned the determination of the Maximum Tolerated Dose (MTD) and/or Maximum Recommended Dose (MRD) of MCLA-128. Which was set to 750mg.The secundary objective of the…
to provide access to Radium-223 dichloride together with abiraterone and prednisone to patients diagnosed with CRPC with bonemetasasis.
The goal of the stomp trial will be to investigate the effectiveness of both the neurolysis and neurectomy procedure in patients with persistent symptoms of meralgia paresthetica. In addition, in this trial we want to determine to what extend…
The aim of the PELICAN trial is to investigate the survival benefit of RFA followed by chemotherapy as compared to standard palliative chemotherapy alone in patients with LAPC.
Primary Objectives:• Determine the safety and tolerability of CC-122 administered in combination with obinutuzumab.• Determine the non-tolerated dose (NTD), maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of CC-122 administered in…
Primary objective:To evaluate whether the addition of lenalidomide to rituximab-maintenance improves progression free survival (PFS) compared to standard rituximab maintenance after response to induction chemotherapy in older patients with mantle…
Protocol v1.0 31-Mar-2014, paragraph 2.1-2.4, pages 37-39:The primary objective of this study is: - To determine the efficacy of Olaparib maintenance monotherapy compared to placebo by progression free survival (PFS).The secundary objectives of this…
We want to examine the effect of the antihistamine Ebastine on abdominal pain and other symptoms associated with IBS and the quality of life. Through this research we would like to emphasize that this study primarily focuses on improvements of the…
In the project *Monitoring Outcomes of Pharmacotherapy (MOPHAR), an infrastructure will be created in which - using standardised protocols - longitudinal monitoring data will be collected regarding Routine Outcome Monitoring (ROM), medication usage…
Currently, there are no curative treatment options for patients with Waldenstrom*s macroglobulinemia (WM) and there is no consensus on standard first line or relapse treatment. The proteasome inhibitor bortezomib has shown efficacy in WM, but is…
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
Systems biology is an interdisciplinary approach that systematically describes the complex interactions between all the parts in a biological system, with a view to elucidating new biological rules capable of predicting the behavior of the…
Primary:• To evaluate the safety of ORGN001 (formerly ALXN1101) over the first 6 months of treatmentSecondary:• To characterize the pharmacokinetics (PK) of increasing doses of ORGN001 (formerly ALXN1101) • To evaluate the effect of ORGN001 (…
The main objective is to compare growth and body composition of late preterm infants at 6 months corrected age, fed either an isocaloric, protein- and mineral-enriched ('postdischarge') formula (PDF) or standard term formula (TF) between…
To develop a *two hit* in vivo autologous PLTs transfusion model in healthy male volunteers
Primary: to characterize the safety and tolerability of GSK3052230 in combination with chemotherapy regimens, to determine the MTD and to assess overall response rate in patients with stage IV or recurrent squamous NSCLC with FGFR1 gene…
The objective of the REPRISE III trial is to evaluate the safety and effectiveness of the Lotus* Valve System for transcatheter aortic valve replacement (TAVR) in symptomatic subjects with calcific, severe native aortic stenosis who are considered…
The aim of this project is to maintain quality of life and improve cancer related outcome by preventing therapy-related toxicity (and ensuing unplanned hospital admission and /or discontinuation of chemotherapy) in cancer patients treated with…
The objective of this study is to assess the efficacy and safety of radium-223 dichloride in subjects with human epidermal growth factor receptor 2 negative (HER2 negative), hormone receptor positive breast cancer with bone metastases treated with…
To validate the Extended Speech Transmission Index (ESTI) model for fluctuating noise in reverberant conditions in both normal hearing and hearing impaired subjects