6123 results
Anxiety, depression and MUPS are common among first-generation non-Western migrants. The problem with the doctor also concerns motivating and treating these patients. The hypothesis is that attention to the social and cultural context of the patient…
Patients after non-cardiac thoracic or abdominal major surgery receive morphine as pain relief medication whereas this is associated with morphine related side effects. In these patients a non-opioid drug could be appropriate for postoperative pain…
We hypothesize that improving vitamin D and K-status by vitamin D3 plus K2 supplementation could have a favorable synergistic decelerating effect on elastin degradation.
It is expected that dopaminergic antagonism by haloperidol 2mg or 3mg wil result in specific inhibition of both bias and disengagement related activity as measured by EEG in combination with computertasks. Specifically, we expect that, dopamine…
Deep brain stimulation influences the HPA axis and glucose- and lipid metabolism in patients with obsessive compulsive disorder (OCD).
1. Compared to unfortified biscuits (UB), consumption of multiple-micronutrient fortified biscuits five days/week for 26-weeks will improve micronutrient status and vertical growth of female adolescents 2. The timing of intervention (before or after…
There is an ongoing discussion on the aetiology of rhinosinusitis-like symptoms (RS). Till recent years, the point of view was to consider RS as a bacterial infection to be treated with antiobiotics. However, most randomized placebo controlled…
Postoperative ileus is a well-known consequence of abdominal surgery which leads to prolonged hospital stay. Over the past years, the implementation of ERAS programs have lead to a reduction in postoperative hospital stay. The use of laxatives after…
We tested, in a randomized, double-blind, placebo-controlled trial, the effects of pregabalin on pain relief, tolerability, health status, and quality of life in patients with central neuropathic pain.
There is accumulating evidence for a possible protective role of vitamin D in the development and disease course of multiple sclerosis (MS). Vitamin D is cheap, easy to administer, and safe. However, intervention studies are few. The first…
A. Rocuronium will induce impairment of carotid body function through blockade of cholinergic neurotransmission in carotid bodies resulting in a reduced or absent ventilatory response to isocapnic hypoxia. B. Sugammadex will completely restore…
Combined pneumococcal vaccination with influenza vaccinatoin reduces the occurrence of RTI in children with recurrent RTI.
A positive effect on mood is expected after LSD (20 µg) compared to placebo. The effect of LSD on mood is expected to differ depending on time of drug administration (morning vs evening).
The aim of this study is making the work incapacity assessments of employees with a depression in the Netherlands more transparantly by using a Protocol Depression, developed by the Dutch Health Counsel. How can the Protocol Depression be…
We hypothesize that the brain dopamine system plays a role in subjective probability processing and we hypothesize that both the brain dopamine and noradrenaline system play a role in subjective value processing.
A large proportion of chronic patients with complex regional pain syndrome type 1 suffer from both neuropathic pain and dystonia. Findings from neurophysiological and intrathecal baclofen studies highlight an impaired inhibitory neurotransmission.…
1) Pre-sleep whey protein ingestion stimulates overnight muscle protein synthesis rates 2) Pre-sleep casein protein ingestion stimulates overnight muscle protein synthesis rates 3) Pre-sleep whey and casein protein do not differ in their impact on…
Fibronectin testing as a triage for women with threatened preterm labor is a cost effective strategy.
Psoas Compartment - Sciatic Nerve Block, as an adjuvant locoregional anesthetic technique, gives sufficient post operative pain reduction after total hip replacement, regardless which long acting local anesthetic ((levo)bupivacaine or ropivacaine in…
Oral administration with regulated release of 60 mg nifedipine a day will reduce the symptoms of patients suffering from complaints of chronic chilblains, as determined in 1st. line health care, provided there is a good tolerancy of the medication.