25 results
The objective of this study is to find out is the way contractions are maesurent during labor are of any influence on the lenght and the way women deliver. It also looks if there is any influence on neonatal outcome.
efficacy of lanreotide LAR in controling total liver volume in patients with hepatic cysts as a result of ADPKD or PCLD
The main objective of this study is to determine whether THC, the primary psychoactive ingredient in cannabis, modulates activity in functional brain systems. We test this by assessing the acute effects of THC on the reward system, the working…
The purpose of this study is to investigate the role of dopamine in learning about sexual reward in healthy females. We suppose that repeated associations between a neutral stimulus and sexual stimulation results, through classical conditioning, in…
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- Validation of the distribution of DBDE in human blood - Screening of 4 different European countries on DBDE in human blood - to collect human blood samples over a period of ten years from 80 subjects over a 10 year period to establish a long term…
To evaluate the urodynamic effects, the safety and tolerability and the clinical efficacy of AV608 compared with placebo in subjects with idiopathic detrusor overactivity
In previous studies is found that the sequence of processes leading to excessive scar formation starts during the operation. Abnormal epidermal-dermal interactions and excessive immune reactions seem to play an important role.On theoretical base an…
To provide an answer to the following questions: 1. In patients with AD, does treatment with a ChEI improve cerebral hemodynamics? 2. Is there less progression of cerebrovascular lesions on follow-up of AD patients receiving ChEI*s? 3. Does this…
Until now there has been a lack of investigations regarding the power of anaesthetics on the EDP.We will measure changes of EDP, CPPedp and autoregulation in each studie.- Study 1 : thiopental (5mg/kg) versus propofol (2mg/kg), - Study 2: etomidate…
Evaluate which PEG (4000 or 3350) is most preferred by children.Evaluate whether a preferable taste of the drug can lead to a better compliance and subsequently to a better success percentage of the treatment of childhood constipation.
Primary:1. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol secretion in the absence of a 5HTP-challenge.2. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol…
A. What are possible causes of MP and what patients variable are asssociated with MP. What is the natural course and prognosis of MP. What is the influence of MP on the quality of life.B. What is the diagnostic value of SSEP en nerve conduction…
Primary objectives:1) Describe the PD effects on plasma ACTH and serum cortisol upon 100 µg hCRH injection with or without a preceding injection of 10 µg dDAVP 2 hours earlier and study the PK-PD relationship (*Block B*). In particular, the outcome…
The primary objective of this trial will be to evaluate the effect of ONO-2506PO (1200 mg once daily) on the slope of respiratory function (slow vital capacity (SVC) expressed as a percentage of the predicted value) over 12 months compared with…
The objectives are to evaluate:- The effect of Org 3236 on prostate volume compared to placebo;- The effect of Org 3236 on LUTS compared to placebo;- The effect of Org 3236 on urinary flow and postvoid residual volume compared toplacebo;- The effect…
Primary • To investigate the safety and tolerability of long-term treatment with 1.5 mg or 3.0 mg of Org 50081 in elderly outpatients with chronic primary insomnia. Secondary • To collect exploratory efficacy data of long-term treatment with Org…
Stage AThe primary objective is:• To compare the relative bioavailability of a single dose of 300 mg LX6171 using a 40mg/mL and an 80mg/mL formulated suspension;• To evaluate plasma concentrations of LX6171 and its major metabolite LP-523122 after a…
Striatal D2 receptor availability will be ascertained in 30 recent abstinent cocaine addicts by [123I]IBZM SPECT. In addition, we will measure drug craving and impulsivity with questionnaires, fMRI/EEG using cue-reactivity and impulsivity paradigms…
Evaluation of the pharmacodynamic and pharmacokinetic effects of multiple doses of ACT-078573 on the pharmacokinetics of a single dose of desipramine